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Recombinant Human Antibody scFv Fragment specifically binds to Human 4-1BB, expressed in E. coli
Target
4-1BB
Type
scFv Fragment from Human IgG4 - kappa
Immunogen
Ectodomain of human 4-1BB recombinant protein.
Species Reactivity
Human
Expression Host
E. coli
Applications
Suitable for use in ELISA, WB, Neut and most other immunological methods.
Purity
>95.0% as determined by analysis by SDS-PAGE.
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
BACKGROUND
Antigen Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.